What is biologics?
Biologic drugs or biologics are produced from living organisms or comprise components of any living organisms. These are genetically engineered proteins targeting specific parts of the immune system to treat the medical indication.
Biologics or biological products have significantly improved the treatment of diseases such as,
- Inflammatory Bowel Disease (IBD)
- Rheumatoid Arthritis (RA)
- Several forms of Cancer
The first biological drug was human insulin and was marketed in 1982. Biologics include a comprehensive variety of therapeutic formulations derived from humans, animals, or microorganisms by using biotechnology or other cutting-edge technologies.
Some examples of biologics include blood & blood components, vaccines, tissues, cells, genes, allergens, and recombinant proteins.
How are Biologics different from Pharmaceutical Drugs?
Biologics are manufactured in a living system, for example, microorganisms, or animal or plant cells.
Many of the biologics are large and complex molecules. Most biologics are manufactured via recombinant DNA technology.
However, a drug is usually manufactured through a chemical process, which implies that it is made by mixing specific chemical ingredients in an ordered process.
How are Biologics Approved?
Like pharmaceutical drugs, for approval of biologics, the application needs to be submitted to the regulatory authorities of the specific countries.
Helping Fracture Heal (Orthobiologics)
Orthobiologics are substances that orthopedic surgeons use to help injuries heal more quickly. They are used to improve the healing of broken bones and injured muscles, tendons, and ligaments. These products are often made from substances that are naturally found in your body. When they are used in higher concentrations, they may help speed up the healing process.
When you injure a bone, muscle, or tendon, there is bleeding into the injured area. This bleeding is the foundation for the healing response. It provides a way for healing factors to reach the injury site.
In addition to bleeding, there are three factors necessary for healing. All three are orthobiologic substances. They include:
Matrix. This can be thought of like the house in which the cells live and where they will thrive and eventually make bone, tendon, or ligament. The matrix material is conductive. This means it can form the building blocks that help fill bone gaps.
Growth factors. These are the many different kinds of proteins necessary for cells to work during the healing process. Some proteins help speed up the healing process, while others help to control it or slow it down. These elements are much like the vitamins that we take every day to try to improve our health and body function.
Stem cells. These are special cells in your body that can turn into certain types of cells. During the healing process, stem cells are called to the area of your body that needs repair. Factors in the area influence the stem cells to become repair cells. Note that the same stem cell that repairs bone can also repair a tendon or ligament.
For more information talk to a healthcare provider.
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